2ZN7

CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes

Summary for 2ZN7

• Entry DOI: 10.2210/pdb2zn7/pdb
• Related: 2BO7 2QBQ 2ZMM
• Descriptor: Tyrosine-protein phosphatase non-receptor type 1, 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid (3 entities in total)
• Functional Keywords: ptp1b, protein-inhibitor complex, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 1
• Total formula weight: 35392.16

Authors

Xu, W.,Wu, J. (deposition date: 2008-04-22, release date: 2008-10-07, Last modification date: 2023-11-01)

• Primary citation: Wan, Z.-K.,Lee, J.,Hotchandani, R.,Moretto, A.,Binnun, E.,Wilson, D.P.,Kirincich, S.J.,Follows, B.C.,Ipek, M.,Xu, W.,Joseph-McCarthy, D.,Zhang, Y.-L.,Tam, M.,Erbe, D.V.,Tobin, J.F.,Li, W.,Tam, S.Y.,Mansour, T.S.,Wu, J.; Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24; Chemmedchem, 3:1525-1529, 2008; PubMed: 18798205; DOI: 10.1002/cmdc.200800188

Experimental method

X-RAY DIFFRACTION (2.1 Å)