2ZN7

CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes

2ZN7 の概要

• エントリーDOI: 10.2210/pdb2zn7/pdb
• 関連するPDBエントリー: 2BO7 2QBQ 2ZMM
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid (3 entities in total)
• 機能のキーワード: ptp1b, protein-inhibitor complex, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35392.16

構造登録者

Xu, W.,Wu, J. (登録日: 2008-04-22, 公開日: 2008-10-07, 最終更新日: 2023-11-01)

• 主引用文献: Wan, Z.-K.,Lee, J.,Hotchandani, R.,Moretto, A.,Binnun, E.,Wilson, D.P.,Kirincich, S.J.,Follows, B.C.,Ipek, M.,Xu, W.,Joseph-McCarthy, D.,Zhang, Y.-L.,Tam, M.,Erbe, D.V.,Tobin, J.F.,Li, W.,Tam, S.Y.,Mansour, T.S.,Wu, J.; Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24; Chemmedchem, 3:1525-1529, 2008; PubMed: 18798205; DOI: 10.1002/cmdc.200800188

実験手法

X-RAY DIFFRACTION (2.1 Å)