2ZM3
Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor
Summary for 2ZM3
Entry DOI | 10.2210/pdb2zm3/pdb |
Related | 1JQH |
Descriptor | Insulin-like growth factor 1 receptor, (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione (3 entities in total) |
Functional Keywords | igfr, protein-inhibitor complex, tyrosine kinase, atp-binding, cleavage on pair of basic residues, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08069 |
Total number of polymer chains | 4 |
Total formula weight | 143073.80 |
Authors | Xu, W.,Mayer, S.C.,Boschelli, F.,Johnson, M.,Dwyer, B. (deposition date: 2008-04-10, release date: 2008-06-10, Last modification date: 2023-11-15) |
Primary citation | Mayer, S.C.,Banker, A.L.,Boschelli, F.,Di, L.,Johnson, M.,Kenny, C.H.,Krishnamurthy, G.,Kutterer, K.,Moy, F.,Petusky, S.,Ravi, M.,Tkach, D.,Tsou, H.R.,Xu, W. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 18:3641-3645, 2008 Cited by PubMed: 18501599DOI: 10.1016/j.bmcl.2008.04.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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