2ZM3
Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Insulin-like growth factor 1 receptor | polymer | 308 | 35342.1 | 4 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (Human) | Insulin-like growth factor I receptor, IGF-I receptor, CD221 antigen |
| 2 | E, F, G, H (A, B, C, D) | (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione | non-polymer | 426.3 | 4 | Chemie (575) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 457 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 981 - 1286 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Gly 979 | - | expression tag |
| Ser 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 141368.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1705.2 | |
| All* | Total formula weight | 143073.8 |
