2ZKH

Human thrombopoietin neutralizing antibody TN1 FAB

Summary for 2ZKH

DescriptorMonoclonal TN1 FAB light chain, Monoclonal TN1 FAB heavy chain (3 entities in total)
Functional Keywordsthrombopoietin, fab fragment(antibody), immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight46727.02
Authors
Arai, S.,Tamada, T.,Honjo, E.,Maeda, Y.,Kuroki, R. (deposition date: 2008-03-21, release date: 2009-03-24, Last modification date: 2017-12-13)
Primary citation
Arai, S.,Shibazaki, C.,Adachi, M.,Honjo, E.,Tamada, T.,Maeda, Y.,Tahara, T.,Kato, T.,Miyazaki, H.,Blaber, M.,Kuroki, R.
An insight into the thermodynamic characteristics of human thrombopoietin complexation with TN1 antibody.
Protein Sci., 25:1786-1796, 2016
PubMed: 27419667 (PDB entries with the same primary citation)
DOI: 10.1002/pro.2985
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2327 0.2% 5.0% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-10-28