2ZJC
TNFR1 selectve TNF mutant; R1-6
Summary for 2ZJC
Entry DOI | 10.2210/pdb2zjc/pdb |
Related | 2E7A |
Descriptor | Tumor necrosis factor, GLYCEROL (3 entities in total) |
Functional Keywords | phage display system, tnfr1 selectivity, tnf, agonist, mutant, cytokine, lipoprotein, membrane, myristate, phosphoprotein, secreted, signal-anchor, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375 |
Total number of polymer chains | 3 |
Total formula weight | 51335.49 |
Authors | Mukai, Y.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2008-03-05, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Mukai, Y.,Shibata, H.,Nakamura, T.,Yoshioka, Y.,Abe, Y.,Nomura, T.,Taniai, M.,Ohta, T.,Ikemizu, S.,Nakagawa, S.,Tsunoda, S.,Kamada, H.,Yamagata, Y.,Tsutsumi, Y. Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant J.Mol.Biol., 385:1221-1229, 2009 Cited by PubMed: 19084540DOI: 10.1016/j.jmb.2008.11.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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