2ZJC
TNFR1 selectve TNF mutant; R1-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tumor necrosis factor | polymer | 157 | 17081.1 | 3 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin |
| 2 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | E, F, G (A, B, C) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 157 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | Lys 87 | engineered mutation |
| Lys 29 | Leu 105 | engineered mutation |
| Ala 31 | Arg 107 | engineered mutation |
| Gly 32 | Arg 108 | engineered mutation |
| Ser 65 | Lys 141 | engineered mutation |
| Pro 90 | Lys 166 | engineered mutation |
| Arg 98 | Lys 174 | engineered mutation |
| Asn 112 | Lys 188 | engineered mutation |
| Pro 128 | Lys 204 | engineered mutation |
| Ser 146 | Glu 222 | engineered mutation |
| Thr 147 | Ser 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51243.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 51335.5 |
