2ZIR
Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP
Summary for 2ZIR
Entry DOI | 10.2210/pdb2zir/pdb |
Related | 2ZIS |
Descriptor | Protein farnesyltransferase subunit alpha, Protein farnesyltransferase subunit beta, GLYCEROL, ... (7 entities in total) |
Functional Keywords | prenyltransferase, transferase, metal-binding, phosphoprotein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 94541.87 |
Authors | Fukami, T.A.,Sogabe, S.,Nagata, Y.,Kondoh, O.,Ishii, N. (deposition date: 2008-02-22, release date: 2009-02-24, Last modification date: 2023-11-01) |
Primary citation | Asoh, K.,Kohchi, M.,Hyoudoh, I.,Ohtsuka, T.,Masubuchi, M.,Kawasaki, K.,Ebiike, H.,Shiratori, Y.,Fukami, T.A.,Kondoh, O.,Tsukaguchi, T.,Ishii, N.,Aoki, Y.,Shimma, N.,Sakaitani, M. Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors Bioorg.Med.Chem.Lett., 19:1753-1757, 2009 Cited by PubMed: 19217288DOI: 10.1016/j.bmcl.2009.01.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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