2ZIR
Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase subunit alpha | polymer | 377 | 44086.1 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Rat) | CAAX farnesyltransferase subunit alpha, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase subunit alpha, GGTase-I-alpha |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 440 | 49004.6 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Rat) | CAAX farnesyltransferase subunit beta, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C, D, H, I, J (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 6 | G (B) | 2-[(S)-(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-N-morpholin-4-yl-7-phenyl-1-benzofuran-5-carboxamide | non-polymer | 543.0 | 1 | Chemie (NH7) | |||
| 7 | K, L (A, B) | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q04631)
B: 1 - 437 (UniProt: Q02293)
| PDB | External Database | Details |
|---|---|---|
| Thr 156 | Ile 156 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93090.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1451.2 | |
| All* | Total formula weight | 94541.9 |
