2ZI6

C4S dCK variant of dCK in complex with D-dA+UDP

Summary for 2ZI6

Entry DOI	10.2210/pdb2zi6/pdb
Related	1P60 2NO1 2NO7 2ZI3 2ZI4 2ZI5 2ZI7 2ZI9 2ZIA
Descriptor	Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, ... (4 entities in total)
Functional Keywords	dck, purine, deoxyadenosine, deoxycytidine kinase, nucleoside, enantiomer, d-da, udp, atp-binding, nucleotide-binding, nucleus, phosphoprotein, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P27707
Total number of polymer chains	4
Total formula weight	132911.65
Authors	Sabini, E.,Lavie, A. (deposition date: 2008-02-13, release date: 2008-04-22, Last modification date: 2023-11-01)
Primary citation	Sabini, E.,Hazra, S.,Ort, S.,Konrad, M.,Lavie, A. Structural basis for substrate promiscuity of dCK J.Mol.Biol., 378:607-621, 2008 Cited by PubMed: 18377927 DOI: 10.1016/j.jmb.2008.02.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation