Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZI6

C4S dCK variant of dCK in complex with D-dA+UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004136	molecular_function	deoxyadenosine kinase activity
A	0004137	molecular_function	deoxycytidine kinase activity
A	0004138	molecular_function	deoxyguanosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0008144	molecular_function	obsolete drug binding
A	0009224	biological_process	CMP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0019136	molecular_function	deoxynucleoside kinase activity
A	0042803	molecular_function	protein homodimerization activity
A	0043771	molecular_function	cytidine kinase activity
A	0106383	biological_process	dAMP salvage
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1901293	biological_process	nucleoside phosphate biosynthetic process
B	0004136	molecular_function	deoxyadenosine kinase activity
B	0004137	molecular_function	deoxycytidine kinase activity
B	0004138	molecular_function	deoxyguanosine kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0008144	molecular_function	obsolete drug binding
B	0009224	biological_process	CMP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0019136	molecular_function	deoxynucleoside kinase activity
B	0042803	molecular_function	protein homodimerization activity
B	0043771	molecular_function	cytidine kinase activity
B	0106383	biological_process	dAMP salvage
B	1901135	biological_process	carbohydrate derivative metabolic process
B	1901293	biological_process	nucleoside phosphate biosynthetic process
C	0004136	molecular_function	deoxyadenosine kinase activity
C	0004137	molecular_function	deoxycytidine kinase activity
C	0004138	molecular_function	deoxyguanosine kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0008144	molecular_function	obsolete drug binding
C	0009224	biological_process	CMP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0019136	molecular_function	deoxynucleoside kinase activity
C	0042803	molecular_function	protein homodimerization activity
C	0043771	molecular_function	cytidine kinase activity
C	0106383	biological_process	dAMP salvage
C	1901135	biological_process	carbohydrate derivative metabolic process
C	1901293	biological_process	nucleoside phosphate biosynthetic process
D	0004136	molecular_function	deoxyadenosine kinase activity
D	0004137	molecular_function	deoxycytidine kinase activity
D	0004138	molecular_function	deoxyguanosine kinase activity
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0008144	molecular_function	obsolete drug binding
D	0009224	biological_process	CMP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0019136	molecular_function	deoxynucleoside kinase activity
D	0042803	molecular_function	protein homodimerization activity
D	0043771	molecular_function	cytidine kinase activity
D	0106383	biological_process	dAMP salvage
D	1901135	biological_process	carbohydrate derivative metabolic process
D	1901293	biological_process	nucleoside phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP A 1301

Chain	Residue
A	ALA1031
A	ASP1241
A	PHE1242
A	LYS1243
A	ALA1032
A	GLY1033
A	LYS1034
A	SER1035
A	THR1036
A	ARG1188
A	LEU1191
A	ARG1192

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP A 2301

Chain	Residue
B	ALA2031
B	ALA2032
B	GLY2033
B	LYS2034
B	SER2035
B	THR2036
B	ARG2188
B	LEU2191
B	ARG2192
B	ASP2241
B	PHE2242
B	LYS2243

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UDP A 3301

Chain	Residue
C	ASN3029
C	ALA3031
C	ALA3032
C	GLY3033
C	LYS3034
C	SER3035
C	THR3036
C	GLU3127
C	ARG3188
C	ARG3192
C	ASP3241
C	PHE3242
C	LYS3243

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP A 4301

Chain	Residue
D	ALA4031
D	ALA4032
D	GLY4033
D	LYS4034
D	SER4035
D	THR4036
D	ARG4188
D	LEU4191
D	ARG4192
D	ASP4241
D	PHE4242
D	LYS4243

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3D1 A 1302

Chain	Residue
A	GLU1053
A	TYR1086
A	PHE1096
A	GLN1097
A	ARG1128
A	ASP1133
A	PHE1137

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 3D1 B 2302

Chain	Residue
B	GLU2053
B	SER2059
B	LEU2082
B	TYR2086
B	PHE2096
B	GLN2097
B	ASP2133
B	PHE2137
B	ILE2200

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 3D1 C 3302

Chain	Residue
C	GLU3053
C	TYR3086
C	GLN3097
C	ASP3133
C	PHE3137
C	ILE3200

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3D1 D 4302

Chain	Residue
D	ILE4030
D	GLU4053
D	TYR4086
D	PHE4096
D	GLN4097
D	ARG4128
D	ASP4133
D	PHE4137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255

Chain	Residue	Details
A	GLU1127
B	GLU2127
C	GLU3127
D	GLU4127

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING:

Chain	Residue	Details
A	ARG1128
A	ASP1133
A	ARG1188
A	GLU1197
A	GLU1240
B	GLY2028
B	GLU2053
B	TYR2086
B	GLN2097
B	ARG2128
B	ASP2133
B	ARG2188
B	GLU2197
B	GLU2240
C	GLY3028
C	GLU3053
C	TYR3086
C	GLN3097
C	ARG3128
C	ASP3133
C	ARG3188
C	GLU3197
C	GLU3240
D	GLY4028
D	GLU4053
D	TYR4086
D	GLN4097
D	ARG4128
D	ASP4133
D	ARG4188
D	GLU4197
D	GLU4240
A	GLY1028
A	GLU1053
A	TYR1086
A	GLN1097

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000305\|PubMed:20637175

Chain	Residue	Details
A	SER1011
A	SER1015
B	SER2011
B	SER2015
C	SER3011
C	SER3015
D	SER4011
D	SER4015

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK1 => ECO:0000305\|PubMed:20637175

Chain	Residue	Details
A	THR1072
B	THR2072
C	THR3072
D	THR4072

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:20637175, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER1074
B	SER2074
C	SER3074
D	SER4074

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)