2ZI6

C4S dCK variant of dCK in complex with D-dA+UDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Deoxycytidine kinase	polymer	279	32572.5	4	UniProt (P27707) Pfam (PF01712)	Homo sapiens (human)	dCK
2	E, F, G, H (A)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	4	Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (3084486) PubChem (60098857) PubChem (57448939) PubChem (6101632) PubChem (6604175) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (11811538) PubChem (93088131) PubChem (93630083) PubChem (12049241)
3	I, J, K, L (A, B, C, D)	(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol	non-polymer		251.2	4	Chemie (3D1)
4	M, N, O, P (A, B, C, D)	water	water		18.0	165	Chemie (HOH)

Sequence modifications

A, B, C, D: 1001 - 1260 (UniProt: P27707)

PDB	External Database	Details
Met 982	-	expression tag
Gly 983	-	expression tag
Ser 984	-	expression tag
Ser 985	-	expression tag
His 986	-	expression tag
His 987	-	expression tag
His 988	-	expression tag
His 989	-	expression tag
His 990	-	expression tag
His 991	-	expression tag
Ser 992	-	expression tag
Gly 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Ser 1009	Cys 9	engineered mutation
Ser 1045	Cys 45	engineered mutation
Ser 1059	Cys 59	engineered mutation
Ser 1146	Cys 146	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130290.0
Non-Polymers*	Number of molecules	8
	Total formula weight	2621.6
All*	Total formula weight	132911.7

*Water molecules are not included.