2ZI6

C4S dCK variant of dCK in complex with D-dA+UDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Deoxycytidine kinase	polymer	279	32572.5	4	UniProt (P27707) Pfam (PF01712) In PDB	Homo sapiens (human)	dCK
2	A	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	4	Chemie (UDP)
3	A, B, C, D	(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol	non-polymer		251.2	4	Chemie (3D1)
4		water	water		18.0	165	Chemie (HOH)

Sequence modifications

A, B, C, D: 1001 - 1260 (UniProt: P27707)

PDB	External Database	Details
Met 982	-	expression tag
Gly 983	-	expression tag
Ser 984	-	expression tag
Ser 985	-	expression tag
His 986	-	expression tag
His 987	-	expression tag
His 988	-	expression tag
His 989	-	expression tag
His 990	-	expression tag
His 991	-	expression tag
Ser 992	-	expression tag
Gly 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Ser 1009	Cys 9	engineered mutation
Ser 1045	Cys 45	engineered mutation
Ser 1059	Cys 59	engineered mutation
Ser 1146	Cys 146	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130290.0
Non-Polymers*	Number of molecules	8
	Total formula weight	2621.6
All*	Total formula weight	132911.7

*Water molecules are not included.