Crystal structure of BACE1 at pH 7.0

Summary for 2ZHV

Related2ZHR 2ZHS 2ZHT 2ZHU
DescriptorBeta-secretase 1 (2 entities in total)
Functional Keywordsph 7.0, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P56817
Total number of polymer chains1
Total molecular weight45900.5
Shimizu, H.,Nukina, N. (deposition date: 2008-02-08, release date: 2008-04-22, Last modification date: 2011-07-13)
Primary citation
Shimizu, H.,Tosaki, A.,Kaneko, K.,Hisano, T.,Sakurai, T.,Nukina, N.
Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production
Mol.Cell.Biol., 28:3663-3671, 2008
PubMed: 18378702 (PDB entries with the same primary citation)
DOI: 10.1128/MCB.02185-07
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29014 1.1% 1.9% 13.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28