2ZEJ
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Summary for 2ZEJ
Entry DOI | 10.2210/pdb2zej/pdb |
Descriptor | Leucine-rich repeat kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | parkinson's disease, lrrk2, roc, gtpase, roco, kinase, atp-binding, disease mutation, gtp-binding, gtpase activation, leucine-rich repeat, membrane, nucleotide-binding, parkinson disease, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 43778.48 |
Authors | Deng, J. (deposition date: 2007-12-13, release date: 2008-01-22, Last modification date: 2017-10-11) |
Primary citation | Deng, J.,Lewis, P.A.,Greggio, E.,Sluch, E.,Beilina, A.,Cookson, M.R. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase Proc.Natl.Acad.Sci.Usa, 105:1499-1504, 2008 Cited by PubMed: 18230735DOI: 10.1073/pnas.0709098105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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