2ZDU

Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor

2ZDU の概要

• エントリーDOI: 10.2210/pdb2zdu/pdb
• 関連するPDBエントリー: 2ZDT
• 分子名称: Mitogen-activated protein kinase 10, 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid (3 entities in total)
• 機能のキーワード: protein kinase, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42623.07

構造登録者

Sogabe, S.,Ohra, T.,Itoh, F.,Habuka, N.,Fujishima, A. (登録日: 2007-11-27, 公開日: 2008-09-23, 最終更新日: 2023-11-01)

• 主引用文献: Asano, Y.,Kitamura, S.,Ohra, T.,Aso, K.,Igata, H.,Tamura, T.,Kawamoto, T.,Tanaka, T.,Sogabe, S.,Matsumoto, S.,Yamaguchi, M.,Kimura, H.,Itoh, F.; Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1); Bioorg.Med.Chem., 16:4715-4732, 2008; PubMed: 18313304; DOI: 10.1016/j.bmc.2008.02.027

実験手法

X-RAY DIFFRACTION (2.5 Å)