2ZDA

Exploring Thrombin S1 pocket

2ZDA の概要

• エントリーDOI: 10.2210/pdb2zda/pdb
• 関連するPDBエントリー: 1H8D 1YPG 2ZC9 2ZDV
• 関連するBIRD辞書のPRD_ID: PRD_000600
• 分子名称: Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-1, ... (7 entities in total)
• 機能のキーワード: blood clotting/hydrolase inhibitors, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35832.64

構造登録者

Baum, B.,Heine, A.,Klebe, G. (登録日: 2007-11-21, 公開日: 2008-10-28, 最終更新日: 2023-11-15)

• 主引用文献: Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G.; Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin; J.Mol.Biol., 391:552-564, 2009; PubMed: 19520086; DOI: 10.1016/j.jmb.2009.06.016

実験手法

X-RAY DIFFRACTION (1.73 Å)