2ZD1

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor

Summary for 2ZD1

• Entry DOI: 10.2210/pdb2zd1/pdb
• Related: 1S6Q 1SV5 2IC3 2ZE2 3BGR 4G1Q
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, SULFATE ION, ... (6 entities in total)
• Functional Keywords: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, rilpivirine, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 114553.28

Authors

Das, K.,Bauman, J.D.,Clark Jr., A.D.,Shatkin, A.J.,Arnold, E. (deposition date: 2007-11-16, release date: 2008-02-12, Last modification date: 2023-11-01)

• Primary citation: Das, K.,Bauman, J.D.,Clark Jr., A.D.,Frenkel, Y.V.,Lewi, P.J.,Shatkin, A.J.,Hughes, S.H.,Arnold, E.; High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.; Proc.Natl.Acad.Sci.Usa, 105:1466-1471, 2008; PubMed: 18230722; DOI: 10.1073/pnas.0711209105

Experimental method

X-RAY DIFFRACTION (1.8 Å)