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2ZD1

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 556
ChainResidue
ALYS331
AGLY333
AGLN334
AHOH775

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE T27 A 557
ChainResidue
APHE227
ATRP229
ALEU234
AHIS235
APRO236
ATYR318
BGLU138
BHOH465
ALEU100
ALYS101
ALYS103
ATYR181
ATYR188

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 429
ChainResidue
BTRP24
BGLU399
BTRP402
BTHR403
BHOH545

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
BASP110
BASP185
BASP186

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization
ChainResidueDetails
BTRP401
BTRP414
AASP498
AASP549

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization
ChainResidueDetails
ATRP401
ATRP414

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial
ChainResidueDetails
APHE440

238268

PDB entries from 2025-07-02

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