2ZC4

Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae

2ZC4 の概要

• エントリーDOI: 10.2210/pdb2zc4/pdb
• 関連するPDBエントリー: 2ZC3 2ZC5 2ZC6
• 分子名称: Penicillin-binding protein 2X, (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, tebipenem, antibiotic resistance, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, membrane, secreted, transmembrane, biosynthetic protein
• 由来する生物種: Streptococcus pneumoniae; 詳細
• 細胞内の位置: Cell membrane; Single-pass membrane protein: P59676 P59676 P59676
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 149229.13

構造登録者

Yamada, M.,Watanabe, T.,Takeuchi, Y. (登録日: 2007-11-02, 公開日: 2008-04-08, 最終更新日: 2023-11-01)

• 主引用文献: Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S.; Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae; Antimicrob.Agents Chemother., 52:2053-2060, 2008; PubMed: 18391040; DOI: 10.1128/AAC.01456-07

実験手法

X-RAY DIFFRACTION (2.8 Å)