2ZB7

Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADPH and nicotinamide

Summary for 2ZB7

Entry DOI	10.2210/pdb2zb7/pdb
Related	2ZB3 2ZB4 2ZB8
Descriptor	Prostaglandin reductase 2, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NICOTINAMIDE, ... (4 entities in total)
Functional Keywords	rossmann fold, alternative splicing, cytoplasm, nadp, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm (By similarity): Q8N8N7
Total number of polymer chains	1
Total formula weight	39828.83
Authors	Wu, Y.H.,Wang, A.H.J.,Ko, T.P.,Guo, R.T.,Hu, S.M.,Chuang, L.M. (deposition date: 2007-10-16, release date: 2008-09-30, Last modification date: 2023-11-01)
Primary citation	Wu, Y.H.,Ko, T.P.,Guo, R.T.,Hu, S.M.,Chuang, L.M.,Wang, A.H.J. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure, 16:1714-1723, 2008 Cited by PubMed: 19000823 DOI: 10.1016/j.str.2008.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation