2ZB4

Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP and 15-keto-PGE2

Summary for 2ZB4

Entry DOI	10.2210/pdb2zb4/pdb
Related	2ZB3 2ZB7 2ZB8
Descriptor	Prostaglandin reductase 2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	rossmann fold, alternative splicing, cytoplasm, nadp, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm (By similarity): Q8N8N7
Total number of polymer chains	1
Total formula weight	40439.39
Authors	Wu, Y.H.,Wang, A.H.J.,Ko, T.P.,Guo, R.T.,Hu, S.M.,Chuang, L.M. (deposition date: 2007-10-16, release date: 2008-09-30, Last modification date: 2023-11-01)
Primary citation	Wu, Y.H.,Ko, T.P.,Guo, R.T.,Hu, S.M.,Chuang, L.M.,Wang, A.H.J. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure, 16:1714-1723, 2008 Cited by PubMed: 19000823 DOI: 10.1016/j.str.2008.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation