2ZB4
Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADP and 15-keto-PGE2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin reductase 2 | polymer | 357 | 38961.3 | 1 | UniProt (Q8N8N7) Pfam (PF16884) Pfam (PF00107) | Homo sapiens (Human) | PTGR2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1 |
| 2 | B, C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | F (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 4 | G (A) | (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID | non-polymer | 350.4 | 1 | Chemie (5OP) PubChem (5353288) PubChem (10405620) PubChem (13746629) PubChem (21158735) PubChem (46937058) PubChem (53477750) PubChem (1441) PubChem (160126) PubChem (51523121) PubChem (5280719) PubChem (98043988) PubChem (54523897) PubChem (57355765) PubChem (16061134) PubChem (71434124) PubChem (71684388) PubChem (71775497) PubChem (92450255) PubChem (98043989) PubChem (98043990) PubChem (124351385) PubChem (124351417) PubChem (137348384) PubChem (155293413) PubChem (156358933) PubChem (156681956) PubChem (162996772) PubChem (168313592) PubChem (171042199) | |||
| 5 | H (A) | water | water | 18.0 | 618 | Chemie (HOH) |
Sequence modifications
A: 1 - 351 (UniProt: Q8N8N7)
| PDB | External Database | Details |
|---|---|---|
| Ala -6 | - | expression tag |
| Ala -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ala -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38961.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1478.1 | |
| All* | Total formula weight | 40439.4 |
