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2ZB7

Crystal structure of human 15-ketoprostaglandin delta-13-reductase in complex with NADPH and nicotinamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0008270molecular_functionzinc ion binding
A0016491molecular_functionoxidoreductase activity
A0016628molecular_functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
A0036132molecular_function13-prostaglandin reductase activity
A0047522molecular_function15-oxoprostaglandin 13-oxidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues39
DetailsBINDING SITE FOR RESIDUE NDP A 900
ChainResidue
APRO50
ATYR208
AASN231
AVAL232
ACYS253
AGLY254
AGLN255
AILE256
ASER257
ATYR259
APHE287
AMET135
ALEU288
AVAL289
AMET332
AMET333
AGLY335
AASN337
AGLY339
AHOH467
AHOH469
AHOH480
ATHR139
AHOH488
AHOH489
AHOH574
AHOH576
AHOH577
AHOH578
AHOH587
AHOH588
AHOH779
ANCA901
AGLY165
AALA166
ACYS167
ACYS187
AGLY188
ALYS192

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NCA A 901
ChainResidue
ATYR51
ALEU288
ALEU290
AHOH468
ANDP900

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING:
ChainResidueDetails
ATYR208
AASN231
ACYS253
APHE287
ALEU288
AASN337
APHE99
AGLY165
ALYS192

221051

PDB entries from 2024-06-12

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