2Z9A

Crystal Structure of Human Saposin C Dimer in Open Conformation

Summary for 2Z9A

Entry DOI	10.2210/pdb2z9a/pdb
Related	2R0R 2R1Q 2RB3 2qyp
Descriptor	Proactivator polypeptide, GLYCEROL (3 entities in total)
Functional Keywords	lipid binding protein, saposin, activator protein, sap, disease mutation, gaucher disease, glycoprotein, gm2-gangliosidosis, lipid metabolism, lysosome, metachromatic leukodystrophy, sphingolipid metabolism
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07602
Total number of polymer chains	2
Total formula weight	20483.44
Authors	Rossmann, M.,Saenger, W.,Maier, T. (deposition date: 2007-09-18, release date: 2008-04-29, Last modification date: 2023-08-30)
Primary citation	Rossmann, M.,Schultz-Heienbrok, R.,Behlke, J.,Remmel, N.,Alings, C.,Sandhoff, K.,Saenger, W.,Maier, T. Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions. Structure, 16:809-817, 2008 Cited by PubMed: 18462685 DOI: 10.1016/j.str.2008.02.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation