2Z9A

Crystal Structure of Human Saposin C Dimer in Open Conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Proactivator polypeptide	polymer	88	10149.6	2	UniProt (P07602) Pfam (PF05184) Pfam (PF03489)	Homo sapiens (human)
2	C, D (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	E, F (A, B)	water	water		18.0	29	Chemie (HOH)

Sequence modifications

A, B: 1 - 79 (UniProt: P07602)

PDB	External Database	Details
Tyr -1	-	expression tag
Val 0	-	expression tag
Arg 80	-	expression tag
His 81	-	expression tag
His 82	-	expression tag
His 83	-	expression tag
His 84	-	expression tag
His 85	-	expression tag
His 86	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20299.3
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	20483.4

*Water molecules are not included.