2Z7S
Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A
Summary for 2Z7S
Entry DOI | 10.2210/pdb2z7s/pdb |
Related | 2Z7Q 2Z7R |
Descriptor | Ribosomal protein S6 kinase alpha-1, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL (3 entities in total) |
Functional Keywords | protein kinase, cancer, kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37166.29 |
Authors | Ikuta, M.,Munshi, S.K. (deposition date: 2007-08-28, release date: 2008-05-13, Last modification date: 2023-11-01) |
Primary citation | Ikuta, M.,Kornienko, M.,Byrne, N.,Reid, J.C.,Mizuarai, S.,Kotani, H.,Munshi, S.K. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci., 16:2626-2635, 2007 Cited by PubMed: 17965187DOI: 10.1110/ps.073123707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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