2Z7H

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-210

2Z7H の概要

• エントリーDOI: 10.2210/pdb2z7h/pdb
• 関連するPDBエントリー: 2Z7I
• 分子名称: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, {1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC ACID), ... (4 entities in total)
• 機能のキーワード: prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, cytoplasm, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Cytoplasm (By similarity): Q12051
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79385.02

構造登録者

Cao, R.,Chen, C.K.-M.,Guo, R.-T.,Hudock, M.,Wang, A.H.-J.,Oldfield, E. (登録日: 2007-08-23, 公開日: 2008-05-06, 最終更新日: 2023-11-01)

• 主引用文献: Cao, R.,Chen, C.K.,Guo, R.T.,Wang, A.H.,Oldfield, E.; Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.; Proteins, 73:431-439, 2008; PubMed: 18442135; DOI: 10.1002/prot.22066

実験手法

X-RAY DIFFRACTION (2.08 Å)