2Z7H

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-210

Summary for 2Z7H

• Entry DOI: 10.2210/pdb2z7h/pdb
• Related: 2Z7I
• Descriptor: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, {1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC ACID), ... (4 entities in total)
• Functional Keywords: prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, cytoplasm, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm (By similarity): Q12051
• Total number of polymer chains: 2
• Total formula weight: 79385.02

Authors

Cao, R.,Chen, C.K.-M.,Guo, R.-T.,Hudock, M.,Wang, A.H.-J.,Oldfield, E. (deposition date: 2007-08-23, release date: 2008-05-06, Last modification date: 2023-11-01)

• Primary citation: Cao, R.,Chen, C.K.,Guo, R.T.,Wang, A.H.,Oldfield, E.; Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.; Proteins, 73:431-439, 2008; PubMed: 18442135; DOI: 10.1002/prot.22066

Experimental method

X-RAY DIFFRACTION (2.08 Å)