2Z5Y

Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine

2Z5Y の概要

• エントリーDOI: 10.2210/pdb2z5y/pdb
• 関連するPDBエントリー: 2Z5X
• 分子名称: Amine oxidase [flavin-containing] A, FLAVIN-ADENINE DINUCLEOTIDE, 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, ... (5 entities in total)
• 機能のキーワード: human monoamine oxidase a, mutant, g110a, fad, harmine, dimethyldecylphosphine oxide, single helix trans-membrane protein, acetylation, catecholamine metabolism, flavoprotein, mitochondrion, neurotransmitter degradation, oxidoreductase, polymorphism, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P21397
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59706.30

構造登録者

Son, S.Y.,Ma, J.,Yoshimura, M.,Tsukihara, T. (登録日: 2007-07-20, 公開日: 2008-04-01, 最終更新日: 2023-11-01)

• 主引用文献: Son, S.Y.,Ma, J.,Kondou, Y.,Yoshimura, M.,Yamashita, E.,Tsukihara, T.; Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors; Proc.Natl.Acad.Sci.Usa, 105:5739-5744, 2008; PubMed: 18391214; DOI: 10.1073/pnas.0710626105

実験手法

X-RAY DIFFRACTION (2.17 Å)