2Z5Y
Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0006576 | biological_process | biogenic amine metabolic process |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008131 | molecular_function | primary methylamine oxidase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019607 | biological_process | phenylethylamine catabolic process |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0042428 | biological_process | serotonin metabolic process |
| A | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 600 |
| Chain | Residue |
| A | ILE19 |
| A | ARG45 |
| A | GLY49 |
| A | GLY50 |
| A | ARG51 |
| A | GLY66 |
| A | GLY67 |
| A | ALA68 |
| A | TYR69 |
| A | PRO243 |
| A | ALA272 |
| A | GLY20 |
| A | ILE273 |
| A | LEU277 |
| A | TRP397 |
| A | TYR402 |
| A | CYS406 |
| A | TYR407 |
| A | GLY434 |
| A | THR435 |
| A | GLY443 |
| A | TYR444 |
| A | GLY21 |
| A | MET445 |
| A | ALA448 |
| A | HOH709 |
| A | HOH723 |
| A | HOH726 |
| A | HOH731 |
| A | HOH742 |
| A | HOH745 |
| A | GLY22 |
| A | ILE23 |
| A | SER24 |
| A | LEU42 |
| A | GLU43 |
| A | ALA44 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE HRM A 700 |
| Chain | Residue |
| A | ILE180 |
| A | ASN181 |
| A | PHE208 |
| A | GLN215 |
| A | ILE335 |
| A | LEU337 |
| A | PHE352 |
| A | TYR407 |
| A | TYR444 |
| A | HOH717 |
| A | HOH882 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DCX A 1 |
| Chain | Residue |
| A | THR489 |
| A | TRP491 |
| A | GLU492 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DCX A 2 |
| Chain | Residue |
| A | TRP116 |
| A | PRO118 |
| A | TYR121 |
| A | THR509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Anchor for type IV membrane protein"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Region: {"description":"Interaction with membrane phospholipid headgroups","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-8alpha-FAD cysteine","evidences":[{"source":"PubMed","id":"18391214","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z5Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| A | GLY71 |
