2Z4Y

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252

2Z4Y の概要

• エントリーDOI: 10.2210/pdb2z4y/pdb
• 関連するPDBエントリー: 2Z4V 2Z4W 2Z4X 2Z4Z 2Z50 2Z52
• 分子名称: Geranylgeranyl pyrophosphate synthetase, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Cytoplasm (By similarity): Q12051
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79535.07

構造登録者

Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (登録日: 2007-06-26, 公開日: 2008-07-01, 最終更新日: 2023-11-01)

• 主引用文献: Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E.; Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation; J.Med.Chem., 51:5594-5607, 2008; PubMed: 18800762; DOI: 10.1021/jm800325y

実験手法

X-RAY DIFFRACTION (2.1 Å)