2Z4B
Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand
Summary for 2Z4B
Entry DOI | 10.2210/pdb2z4b/pdb |
Related | 2I0G 2I0J 2Q70 |
Descriptor | Estrogen receptor beta, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3 entities in total) |
Functional Keywords | nuclear receptor ligand binding domain, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q92731 |
Total number of polymer chains | 2 |
Total formula weight | 59093.93 |
Authors | Wang, Y. (deposition date: 2007-06-14, release date: 2007-08-07, Last modification date: 2024-02-21) |
Primary citation | Richardson, T.I.,Dodge, J.A.,Durst, G.L.,Pfeifer, L.A.,Shah, J.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Norman, B.H. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification. Bioorg.Med.Chem.Lett., 17:4824-4828, 2007 Cited by PubMed: 17614275DOI: 10.1016/j.bmcl.2007.06.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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