2Z3Q

Crystal structure of the IL-15/IL-15Ra complex

2Z3Q の概要

• エントリーDOI: 10.2210/pdb2z3q/pdb
• 関連するPDBエントリー: 2Z3R
• 分子名称: Interleukin-15, Interleukin-15 receptor alpha chain (3 entities in total)
• 機能のキーワード: protein-protein complex, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm: P40933; Membrane; Single-pass type I membrane protein. Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space: Q13261
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 49508.30

構造登録者

Chirifu, M.,Yamagata, Y.,Davis, S.J.,Ikemizu, S. (登録日: 2007-06-05, 公開日: 2007-09-04, 最終更新日: 2011-07-13)

• 主引用文献: Chirifu, M.,Hayashi, C.,Nakamura, T.,Toma, S.,Shuto, T.,Kai, H.,Yamagata, Y.,Davis, S.J.,Ikemizu, S.; Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans; Nat.Immunol., 8:1001-1007, 2007; PubMed: 17643103; DOI: 10.1038/ni1492

実験手法

X-RAY DIFFRACTION (1.85 Å)