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2Z0P

Crystal structure of PH domain of Bruton's tyrosine kinase

Summary for 2Z0P
Entry DOI10.2210/pdb2z0p/pdb
DescriptorTyrosine-protein kinase BTK, ZINC ION, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ... (4 entities in total)
Functional Keywordsph domain, pip3c4, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphorylation, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc-finger, signaling protein, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q06187
Total number of polymer chains4
Total formula weight83059.09
Authors
Murayama, K.,Kato-Murayama, M.,Mishima, C.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-05-07, release date: 2008-05-13, Last modification date: 2023-11-01)
Primary citationMurayama, K.,Kato-Murayama, M.,Mishima, C.,Akasaka, R.,Shirouzu, M.,Fukui, Y.,Yokoyama, S.
Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol
Biochem.Biophys.Res.Commun., 377:23-28, 2008
Cited by
PubMed: 18809383
DOI: 10.1016/j.bbrc.2008.09.055
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.58 Å)
Structure validation

217705

數據於2024-03-27公開中

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