2YOL
West Nile Virus NS2B-NS3 protease in complex with 3,4- dichlorophenylacetyl-Lys-Lys-GCMA
2YOL の概要
エントリーDOI | 10.2210/pdb2yol/pdb |
分子名称 | SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3, CHLORIDE ION, (S)-6-amino-N-((S)-6-amino-1-(((1r,4S)-4-guanidinocyclohexyl)methylamino)-1-oxohexan-2-yl)-2-(2-(3,4-dichlorophenyl)acetamido)hexanamide, ... (5 entities in total) |
機能のキーワード | serine protease, hydrolase, inhibitor |
由来する生物種 | WEST NILE VIRUS |
細胞内の位置 | Capsid protein C: Virion (Potential). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P06935 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25310.15 |
構造登録者 | Hammamy, M.Z.,Haase, C.,Hammami, M.,Hilgenfeld, R.,Steinmetzer, T. (登録日: 2012-10-25, 公開日: 2013-03-27, 最終更新日: 2023-12-20) |
主引用文献 | Hammamy, M.Z.,Haase, C.,Hammami, M.,Hilgenfeld, R.,Steinmetzer, T. Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus Ns2B-Ns3 Protease. Chemmedchem, 8:231-, 2013 Cited by PubMed: 23307694DOI: 10.1002/CMDC.201200497 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
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