Solution structure of the closed conformation of human U2AF65 tandem RRM1 and RRM2 domains

Summary for 2YH0

Related2U2F 1U2F 1OPI 1O0P 2G4B 1JMT 2YH4 2YH1
DescriptorSPLICING FACTOR U2AF 65 KDA SUBUNIT (1 entity in total)
Functional Keywordspre-mrna splicing, transcription, rna binding protein, mrna processing
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight21510.53
Mackereth, C.D.,Madl, T.,Simon, B.,Zanier, K.,Gasch, A.,Sattler, M. (deposition date: 2011-04-26, release date: 2011-07-20, Last modification date: 2019-09-25)
Primary citation
Mackereth, C.D.,Madl, T.,Bonnal, S.,Simon, B.,Zanier, K.,Gasch, A.,Rybin, V.,Valcarcel, J.,Sattler, M.
Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af
Nature, 475:408-, 2011
PubMed: 21753750 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE10171
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers7 0.1% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-11-25