2YEK

Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GSK525762 (IBET)

2YEK の概要

• エントリーDOI: 10.2210/pdb2yek/pdb
• 関連するPDBエントリー: 1X0J 2YDW 2YEL 2YEM
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 2, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: signaling protein, histone, epigenetic reader
• 由来する生物種: HOMO SAPIENS
• 細胞内の位置: Nucleus (Probable): P25440
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54706.39

構造登録者

Chung, C.W. (登録日: 2011-03-25, 公開日: 2011-06-15, 最終更新日: 2024-05-08)

• 主引用文献: Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E.; Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.; J.Med.Chem., 54:3827-, 2011; PubMed: 21568322; DOI: 10.1021/JM200108T

実験手法

X-RAY DIFFRACTION (1.98 Å)