2YEK
Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GSK525762 (IBET)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EAM A 1188 |
| Chain | Residue |
| A | TRP97 |
| A | HOH2120 |
| B | GLN94 |
| A | PRO98 |
| A | VAL103 |
| A | LEU110 |
| A | ASN156 |
| A | ILE162 |
| A | HOH2053 |
| A | HOH2070 |
| A | HOH2119 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EAM B 1183 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PRO98 |
| B | LEU110 |
| B | ASN156 |
| B | ILE162 |
| B | HOH2049 |
| B | HOH2100 |
| B | HOH2101 |
| B | HOH2126 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1182 |
| Chain | Residue |
| B | ARG100 |
| B | HOH2010 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH2115 |
| C | HOH2116 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE EAM C 1183 |
| Chain | Residue |
| A | GLN80 |
| A | PRO181 |
| C | TRP97 |
| C | PRO98 |
| C | VAL103 |
| C | LEU110 |
| C | ASN156 |
| C | ASP161 |
| C | ILE162 |
| C | HOH2037 |
| C | HOH2047 |
| C | HOH2098 |
| C | HOH2099 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
