2YDP

Structure of the E242A mutant of the alpha-l-arabinofuranosidase arb93a from fusarium graminearum in complex with an iminosugar inhibitor

Summary for 2YDP

Entry DOI	10.2210/pdb2ydp/pdb
Related	2YDT
Descriptor	EXO-1,5-ALPHA-L-ARABINOFURANOBIOSIDASE, 1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL, alpha-L-arabinofuranose, ... (5 entities in total)
Functional Keywords	hydrolase, glycosyl hydrolase
Biological source	GIBBERELLA ZEAE
Total number of polymer chains	3
Total formula weight	124160.03
Authors	Goddard-Borger, E.D.,Carapito, R.,Jeltsch, J.M.,Phalip, V.,Stick, R.V.,Varrot, A. (deposition date: 2011-03-24, release date: 2011-07-13, Last modification date: 2023-12-20)
Primary citation	Goddard-Borger, E.D.,Carapito, R.,Jeltsch, J.,Phalip, V.,Stick, R.V.,Varrot, A. Alpha-L-Arabinofuranosylated Pyrrolidines as Arabinanase Inhibitors. Chem.Commun.(Camb.), 47:9684-, 2011 Cited by PubMed Abstract: As part of continued efforts to understand the mechanisms of 1,5-α-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant. PubMed: 21773614 DOI: 10.1039/C1CC13675E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation