2YCP

F448H mutant of tyrosine phenol-lyase from Citrobacter freundii in complex with quinonoid intermediate formed with 3-fluoro-L-tyrosine

Summary for 2YCP

Entry DOI	10.2210/pdb2ycp/pdb
Related	2YCN 2YCT
Descriptor	TYROSINE PHENOL-LYASE, (2E)-3-(3-fluoro-4-hydroxyphenyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}propanoic acid, TRIETHYLENE GLYCOL, ... (10 entities in total)
Functional Keywords	lyase, pyridoxal 5'-phosphate dependent enzyme, beta-elimination
Biological source	CITROBACTER FREUNDII
Total number of polymer chains	4
Total formula weight	212189.38
Authors	Milic, D.,Demidkina, T.V.,Faleev, N.G.,Phillips, R.S.,Matkovic-Calogovic, D.,Antson, A.A. (deposition date: 2011-03-16, release date: 2011-09-14, Last modification date: 2023-12-20)
Primary citation	Milic, D.,Demidkina, T.V.,Faleev, N.G.,Phillips, R.S.,Matkovic-Calogovic, D.,Antson, A.A. Crystallographic Snapshots of Tyrosine Phenol-Lyase Show that Substrate Strain Plays a Role in C-C Bond Cleavage J.Am.Chem.Soc., 133:16468-, 2011 Cited by PubMed: 21899319 DOI: 10.1021/JA203361G PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation