2YBP

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)

2YBP の概要

• エントリーDOI: 10.2210/pdb2ybp/pdb
• 関連するPDBエントリー: 2GF7 2GFA 2GP3 2GP5 2V1D 2VD7 2WWJ 2YBK 2YBS
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ... (7 entities in total)
• 機能のキーワード: oxidoreductase-peptide complex, non-heme iron, dioxygenase, double-stranded beta helix, dsbh, facial triad, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation, oxidoreductase/peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92002.30

構造登録者

Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (登録日: 2011-03-09, 公開日: 2011-03-30, 最終更新日: 2023-12-20)

• 主引用文献: Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.; EMBO Rep., 12:463-469, 2011; PubMed: 21460794; DOI: 10.1038/embor.2011.43

実験手法

X-RAY DIFFRACTION (2.02 Å)