2Y88
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PHOSPHORIBOSYL ISOMERASE (VARIANT D11N) WITH BOUND PRFAR
Summary for 2Y88
Entry DOI | 10.2210/pdb2y88/pdb |
Related | 2Y85 2Y89 |
Descriptor | PHOSPHORIBOSYL ISOMERASE A, [(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total) |
Functional Keywords | aromatic amino acid biosynthesis, isomerase, tim-barrel, histidine biosynthesis, tryptophan biosynthesis |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 1 |
Total formula weight | 26235.11 |
Authors | Kuper, J.,Due, A.V.,Geerlof, A.,Wilmanns, M. (deposition date: 2011-02-03, release date: 2011-03-02, Last modification date: 2023-12-20) |
Primary citation | Due, A.V.,Kuper, J.,Geerlof, A.,Kries, J.P.,Wilmanns, M. Bisubstrate Specificity in Histidine/Tryptophan Biosynthesis Isomerase from Mycobacterium Tuberculosis by Active Site Metamorphosis. Proc.Natl.Acad.Sci.USA, 108:3554-, 2011 Cited by PubMed: 21321225DOI: 10.1073/PNAS.1015996108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.33 Å) |
Structure validation
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