2Y68
Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial MurD ligase
2Y68 の概要
エントリーDOI | 10.2210/pdb2y68/pdb |
関連するPDBエントリー | 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 2X5O 2Y1O 2Y66 2Y67 3UAG 4UAG |
分子名称 | UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, 2-[[2-fluoro-5-[[[4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino]methyl]phenyl]carbonylamino]pentanedioic acid, DIMETHYL SULFOXIDE, ... (7 entities in total) |
機能のキーワード | atp-binding, cell cycle, cell division, cell shape, cell wall, cell wall biogenesis/degradation, ligase, nucleotide-binding, peptidoglycan synthesis, uma |
由来する生物種 | Escherichia coli K-12 |
細胞内の位置 | Cytoplasm: P14900 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 49311.91 |
構造登録者 | Tomasic, T.,Zidar, N.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Muller-Premru, M.,Zega, A.,Gobec, S.,Peterlin-Masic, L.,Kikelj, D. (登録日: 2011-01-20, 公開日: 2011-06-08, 最終更新日: 2023-12-20) |
主引用文献 | Tomasic, T.,Zidar, N.,Sink, R.,Kovac, A.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Muller-Premru, M.,Zega, A.,Gobec, S.,Kikelj, D.,Masic, L.P. Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). J. Med. Chem., 54:4600-4610, 2011 Cited by PubMed: 21591605DOI: 10.1021/jm2002525 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.49 Å) |
構造検証レポート
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