2Y67
New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation
Summary for 2Y67
Entry DOI | 10.2210/pdb2y67/pdb |
Related | 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 2X5O 2Y1O 2Y66 2Y68 3UAG 4UAG |
Descriptor | UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (2R)-2-[[4-[[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl]phenyl]sulfonylamino]pentanedioic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | atp-binding, cell cycle, cell division, cell shape, cell wall, cell wall biogenesis/degradation, ligase, nucleotide-binding, peptidoglycan synthesis, uma |
Biological source | ESCHERICHIA COLI |
Cellular location | Cytoplasm: P14900 |
Total number of polymer chains | 1 |
Total formula weight | 48595.99 |
Authors | Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Muller-Premru, M.,Zega, A.,Gobec, S.,Peterlin-Masic, L.,Kikelj, D. (deposition date: 2011-01-20, release date: 2011-10-19, Last modification date: 2023-12-20) |
Primary citation | Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Premru, M.M.,Zega, A.,Gobec, S.,Masic, L.P.,Kikelj, D. New 5-Benzylidenethiazolidin-4-One Inhibitors of Bacterial Murd Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation. Eur.J.Med.Chem, 46:5512-, 2011 Cited by PubMed: 21963114DOI: 10.1016/J.EJMECH.2011.09.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report