2Y66

New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation

2Y66 の概要

• エントリーDOI: 10.2210/pdb2y66/pdb
• 関連するPDBエントリー: 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 2WJP 2X5O 2Y1O 2Y67 2Y68 3UAG 4UAG
• 分子名称: UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (2R)-2-[[3-[[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]methyl]phenyl]carbonylamino]pentanedioic acid, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: atp-binding, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase, nucleotide-binding, peptidoglycan synthesis, uma
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cytoplasm: P14900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48753.59

構造登録者

Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Muller-Premru, M.,Zega, A.,Gobec, S.,Peterlin-Masic, L.,Kikelj, D. (登録日: 2011-01-20, 公開日: 2011-10-19, 最終更新日: 2023-12-20)

• 主引用文献: Zidar, N.,Tomasic, T.,Sink, R.,Kovac, A.,Patin, D.,Blanot, D.,Contreras-Martel, C.,Dessen, A.,Premru, M.M.,Zega, A.,Gobec, S.,Masic, L.P.,Kikelj, D.; New 5-Benzylidenethiazolidin-4-One Inhibitors of Bacterial Murd Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation.; Eur.J.Med.Chem, 46:5512-, 2011; PubMed: 21963114; DOI: 10.1016/J.EJMECH.2011.09.017

実験手法

X-RAY DIFFRACTION (1.49 Å)