2Y4I

KSR2-MEK1 heterodimer

Summary for 2Y4I

• Entry DOI: 10.2210/pdb2y4i/pdb
• Descriptor: KINASE SUPPRESSOR OF RAS 2, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: transferase, ksr1
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 81545.19

Authors

Brennan, D.F.,Barford, D. (deposition date: 2011-01-06, release date: 2011-01-19, Last modification date: 2023-12-20)

• Primary citation: Brennan, D.F.,Dar, A.C.,Hertz, N.T.,Chao, W.,Burlingame, A.L.,Shokat, K.M.,Barford, D.; A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek; Nature, 472:366-, 2011; PubMed: 21441910; DOI: 10.1038/NATURE09860

Experimental method

X-RAY DIFFRACTION (3.46 Å)