2Y1W

CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR

2Y1W の概要

関連するPDBエントリー2Y1X
分子名称HISTONE-ARGININE METHYLTRANSFERASE CARM1, SINEFUNGIN, 2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE, ... (4 entities in total)
機能のキーワードhistone modification, transferase
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Nucleus Q86X55
ポリマー鎖数4
分子量合計160971.13
構造登録者
主引用文献
Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A.
Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors
Biochem.J., 436:331-, 2011
PubMed: 21410432 (主引用文献が同じPDBエントリー)
DOI: 10.1042/BJ20102161
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.1 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.193902.7%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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