2XYU

Crystal structure of EphA4 kinase domain in complex with VUF 12058

Summary for 2XYU

Entry DOI	10.2210/pdb2xyu/pdb
Related	1B0X
Descriptor	EPHRIN TYPE-A RECEPTOR 4,, GLYCEROL, 5-(5-FLUORO-2-METHYLPHENYL)-6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[3,4-C]ISOQUINOLIN-1-AMINE, ... (4 entities in total)
Functional Keywords	signaling protein, transferase
Biological source	MUS MUSCULUS (MOUSE)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q03137
Total number of polymer chains	1
Total formula weight	33081.23
Authors	Farenc, C.J.A.,Celie, P.H.N.,vanLinden, O.P.J.,Siegal, G. (deposition date: 2010-11-19, release date: 2011-11-30, Last modification date: 2023-12-20)
Primary citation	Van Linden, O.P.,Farenc, C.J.A.,Zoutman, W.H.,Hameetman, L.,Wijtmans, M.,Leurs, R.,Tensen, C.P.,Siegal, G.,De Esch, I.J. Fragment Based Lead Discovery of Small Molecule Inhibitors for the Epha4 Receptor Tyrosine Kinase. Eur.J.Med.Chem., 47:493-, 2012 Cited by PubMed: 22137457 DOI: 10.1016/J.EJMECH.2011.11.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.117 Å)

Structure validation