2XU1

CATHEPSIN L WITH A NITRILE INHIBITOR

Summary for 2XU1

Entry DOI	10.2210/pdb2xu1/pdb
Related	1CJL 1CS8 1ICF 1MHW 2VHS 2XU3 2XU4 2XU5
Descriptor	CATHEPSIN L1, (2S,4R)-1-[1-(4-chlorophenyl)cyclopropyl]carbonyl-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide (3 entities in total)
Functional Keywords	hydrolase, drug design, thiol protease
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Lysosome: P07711
Total number of polymer chains	4
Total formula weight	98784.52
Authors	Banner, D.W.,Benz, J.M.,Steinbacher, S.,Haap, W. (deposition date: 2010-10-14, release date: 2011-01-12, Last modification date: 2024-10-23)
Primary citation	Hardegger, L.A.,Kuhn, B.,Spinnler, B.,Anselm, L.,Ecabert, R.,Stihle, M.,Gsell, B.,Thoma, R.,Diez, J.,Benz, J.,Plancher, J.M.,Hartmann, G.,Banner, D.W.,Haap, W.,Diederich, F. Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 50:314-, 2011 Cited by PubMed: 21184410 DOI: 10.1002/ANIE.201006781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation