2XR9

Crystal structure of Autotaxin (ENPP2)

Summary for 2XR9

Entry DOI	10.2210/pdb2xr9/pdb
Related	2XRG
Descriptor	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, THIOCYANATE ION, ... (8 entities in total)
Functional Keywords	hydrolase, lysophosphatidylcholine, somatomedin, inflammation, metastasis, neuropathic pain, vascular development, neural development
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Total number of polymer chains	1
Total formula weight	99684.71
Authors	Kamtekar, S.,Hausmann, J.,Day, J.E.,Christodoulou, E.,Perrakis, A. (deposition date: 2010-09-13, release date: 2011-01-19, Last modification date: 2023-12-20)
Primary citation	Hausmann, J.,Kamtekar, S.,Christodoulou, E.,Day, J.E.,Wu, T.,Fulkerson, Z.,Albers, H.M.,van Meeteren, L.A.,Houben, A.J.,van Zeijl, L.,Jansen, S.,Andries, M.,Hall, T.,Pegg, L.E.,Benson, T.E.,Kasiem, M.,Harlos, K.,Kooi, C.W.,Smyth, S.S.,Ovaa, H.,Bollen, M.,Morris, A.J.,Moolenaar, W.H.,Perrakis, A. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat. Struct. Mol. Biol., 18:198-204, 2011 Cited by PubMed: 21240271 DOI: 10.1038/nsmb.1980 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation